| Authors | Anna Merlotti, Rosario Mazzola, Daniela Alterio, Filippo Alongi, Almalina Bacigalupo, Pierluigi Bonomo, Marta Maddalo, Elvio Grazioso Russi, Ester Orlandi |
| ABSTRACT: |
Re-irradiation has been increasingly offered as a potential effective treatment for head and neck squamouscell carcinoma (HNSCC) loco-regional recurrence as well as second primary tumor in previously irradiatedarea. This review focused on the role of postoperative re-irradiation (POreRT) in terms of feasibility,toxicity and long-term outcomes in HNSCC patients. The key issue for the research was formulated in twoquestions according to the PICO (population, intervention, control, and outcomes) criteria. A total of 16publications met the inclusion criteria for a total of 919 patients; in 522 patients POreRT was performed.POreRT in recurrent and second primary HNSCC seems to be feasible in highly selected patients with the intent to guarantee an acceptable LC compared to surgery alone. The optimal RT schedule remains clear due to the heterogeneity of literature data. |
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