26 Feb 2017
Lezioni di metodologia da youtube (In italiano dal congresso FADOI)
La domanda Clinica (P.I.C.O.) Pregi e difetti di uno studio di diagnosi e di prognosi, perché leggerlo e come considerarlo Pregi e difetti di uno studio osservazionale, perchè leggerlo e come considerarlo; Pregi e difetti di uno studio di intervento, perché leggerlo e come considerarlo Revisioni sistematiche e meta-analisi, pregi e difetti Pregi e Difetti […]
Statistics corner
Statistics Corner: Confidence Intervals Statistics Corner: Overview of Regression Analysis Intention-to-treat analysis: What is it and why is it important? Power, Type II error, and Sample Size How reliable is a physical exam maneuver? (Precision) How to Interpret and Use a Relative Risk and an Odds Ratio What is Heterogeneity? Interpreting Hazard Ratios Fixed Effects […]
EBM part 1 lessons 1-6
What is EBM?; Steps of Practicing EBM: Haynes’ 6S approach to find high quality evidence Benefits of reading a pre-appraised medical literature Primary research study Developing answerable clinical questions
EBM part 2 Lessons 7-12
7. DIAGNOSTIC PROCESS 8. How to Choose a Diagnostic Test 9. What are Clinical prediction rules? 10. What Are Likelihood Ratios and How Are They Used 11. PROGNOSTIC STUDY DESIGN 12. How to Interpret the Results of Prognostic Studies
25 Feb 2017
EBM part 3 Lessons 13-19
13. Why Randomization is important; 14. Composite Endpoints: Useful but sometimes Misleading 15.Relative Risk Reduction Can Be Relatively Misleading 16. Cohort study a brief overview 17. Case-Control Studies: A Brief Overview 18. Overview of Review Articles 19. Principles of Screening
Approach to Reading a Clinical Research Study – critical appraisal
How to Critically Appraise a Diagnostic Test Study Dr Shaneyfelt’s Approach to Reading a Clinical Research Study How to Critically Appraise a Prognosis Study How to Critically Appraise a Therapy Study- Part 1 How to Critically Appraise a Therapy Study- Part 2 How to Critically Appraise a Harm Study- Part 1 How to Critically Appraise […]
12 Feb 2017
DNA Damage Repairing Single-strand damage (SSD)
Fu, D., Calvo, J.A., Samson, L.D., 2012. Balancing repair and tolerance of DNA damage caused by alkylating agents. Nat Rev Cancer 12, 104–120. doi:10.1038/nrc3185 Sources of DNA damage and their repair. Endogenous and environmental sources of DNA damage are shown in green boxes, with the lesions they cause in beige boxes (where known, the approximate […]
10 Feb 2017
Calculations Made in Studies
How to calculate relative risk How to calculate an odds ratio How to Calculate Specificity How to Calculate Sensitivity How to Calculate Positive Predictive Value How to Calculate Negative Predictive Value How to Calculate a Positive Likelihood Ratio How to Calculate a Negative Likelihood Ratio How to Calculate Relative Risk Reduction How To Calculate The […]
5 Feb 2017
DNA double-strand break (DSB) repair
DSD REPAIR (BRCA1-2 depending) Fu, D., Calvo, J.A., Samson, L.D., 2012. Balancing repair and tolerance of DNA damage caused by alkylating agents. Nat Rev Cancer 12, 104–120. doi:10.1038/nrc3185 Sources of DNA damage and their repair. Endogenous and environmental sources of DNA damage are shown in green boxes, with the lesions they cause in beige […]
