12 Feb 2017
DNA Damage Repairing Single-strand damage (SSD)
Fu, D., Calvo, J.A., Samson, L.D., 2012. Balancing repair and tolerance of DNA damage caused by alkylating agents. Nat Rev Cancer 12, 104–120. doi:10.1038/nrc3185 Sources of DNA damage and their repair. Endogenous and environmental sources of DNA damage are shown in green boxes, with the lesions they cause in beige boxes (where known, the approximate […]
5 Feb 2017
DNA double-strand break (DSB) repair
DSD REPAIR (BRCA1-2 depending) Fu, D., Calvo, J.A., Samson, L.D., 2012. Balancing repair and tolerance of DNA damage caused by alkylating agents. Nat Rev Cancer 12, 104–120. doi:10.1038/nrc3185 Sources of DNA damage and their repair. Endogenous and environmental sources of DNA damage are shown in green boxes, with the lesions they cause in beige […]
1 Feb 2017
SYNTHETIC LETHAL STRATEGY
Lauren Pecorino “Molecular Biology of Cancer -Mechanisms, Targets, and Therapeutics. Oxford University 2012 Synthetic lethality. Normal cells have functional DNA repair pathways so that they respond appropriately to damage by activating either pathway A or pathway B. There may also be an inappropriate pathway C that would incorrectly activate cell death in response to the […]
30 Gen 2015
Part: 1-3/ 16 video:- Craig et al: Molecular Biology 2e Oxford Academic (Oxford University Press) Ultimo aggiornamento in data 02 dic 2014
Filmati 1-3 1- Dna Replication; 2- DNA fork coupling; 3- Mitosis and cell division 1- 2- 3-
29 Gen 2015
Part: 4-6/ 16 video:- Craig et al: Molecular Biology 2e Oxford Academic (Oxford University Press) Ultimo aggiornamento in data 02 dic 2014
Filmati 4-6 4 – Transcription; 5- Transcription regulation 6- mRNA Splicing 4- 5- 6-
28 Gen 2015
Part: 7-9/ 16 video:- Craig et al: Molecular Biology 2e Oxford Academic (Oxford University Press) Ultimo aggiornamento in data 02 dic 2014
7-The regulation of splicesome-mediated splicing 8- Translation 9- REgulation of Translation 7- 8- 9-
26 Gen 2015
Part: 10-12/ 16 video:- Craig et al: Molecular Biology 2e Oxford Academic (Oxford University Press) Ultimo aggiornamento in data 02 dic 2014
Filmati 10-12 10 – Generation and action of siRNAs and miRNAs 11- Ubiquitin 12- Non-homologous end joining 4- 5- 6-
19 Gen 2015
Part: 13-16/ 16 video:- Craig et al: Molecular Biology 2e Oxford Academic (Oxford University Press) Ultimo aggiornamento in data 02 dic 2014
Filmati 13-16 13 – Homology-dependent double strand break repair 14- Holliday junction resolution 15- DNA cut and paste transposition 16- the retroviral and retroviral-like transposon lifecycle 4- 5- 6- 6-
